CLEF: Clinically-Guided Contrastive Learning for Electrocardiogram Foundation Models

arXiv — cs.LGWednesday, December 3, 2025 at 5:00:00 AM
  • A novel approach called CLEF has been introduced, utilizing clinically-guided contrastive learning for electrocardiogram (ECG) foundation models. This method leverages clinical metadata to improve the diagnostic performance of single-lead ECG recordings, which are increasingly used in both clinical and consumer settings. The model was pretrained on a substantial dataset of 12-lead ECGs from 161,000 patients in the MIMIC-IV database.
  • The development of CLEF is significant as it enhances the accuracy of ECG diagnostics without the need for extensive per-sample annotations. By integrating clinical risk scores to adaptively weight negative pairs, the model aligns ECG embeddings with clinically relevant differences, potentially leading to better patient outcomes and more effective monitoring of cardiovascular health.
  • This advancement reflects a broader trend in the integration of artificial intelligence with healthcare, particularly in the analysis of electronic health records (EHRs) and vital sign predictions. The emergence of models like CLEF, alongside others focused on SQL correction and EHR reasoning, highlights the ongoing efforts to improve the reliability and interpretability of AI applications in clinical settings, addressing challenges such as data noise and the need for accurate medical insights.
— via World Pulse Now AI Editorial System

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