arXiv:2511.11293v1 Announce Type: new 
Abstract: Current cancer screening guidelines cover only a few cancer types and rely on narrowly defined criteria such as age or a single risk factor like smoking history, to identify high-risk individuals. Predictive models using electronic health records (EHRs), which capture large-scale longitudinal patient-level health information, may provide a more effective tool for identifying high-risk groups by detecting subtle prediagnostic signals of cancer. Recent advances in large language and foundation models have further expanded this potential, yet evidence remains limited on how useful HER-based models are compared with traditional risk factors currently used in screening guidelines. We systematically evaluated the clinical utility of EHR-based predictive models against traditional risk factors, including gene mutations and family history of cancer, for identifying high-risk individuals across eight major cancers (breast, lung, colorectal, prostate, ovarian, liver, pancreatic, and stomach), using data from the All of Us Research Program, which integrates EHR, genomic, and survey data from over 865,000 participants. Even with a baseline modeling approach, EHR-based models achieved a 3- to 6-fold higher enrichment of true cancer cases among individuals identified as high risk compared with traditional risk factors alone, whether used as a standalone or complementary tool. The EHR foundation model, a state-of-the-art approach trained on comprehensive patient trajectories, further improved predictive performance across 26 cancer types, demonstrating the clinical potential of EHR-based predictive modeling to support more precise and scalable early detection strategies.

تقتصر إرشادات الفحص الحالية للسرطان على عدد قليل من أنواع السرطان وتعتمد على معايير محددة مثل العمر أو تاريخ التدخين لتحديد الأفراد المعرضين لخطر مرتفع. تقيّم دراسة فعالية النماذج التنبؤية التي تستخدم السجلات الصحية الإلكترونية (EHR) لتحديد المجموعات عالية المخاطر من خلال الكشف عن إشارات ما قبل التشخيص الدقيقة للسرطان. تركز الأبحاث على ثمانية أنواع رئيسية من السرطان، بما في ذلك سرطان الثدي والرئة، وتقارن النماذج المعتمدة على السجلات الصحية بالعوامل التقليدية.

Las pautas actuales de detección del cáncer son limitadas a unos pocos tipos de cáncer y dependen de criterios específicos como la edad o el historial de tabaquismo para identificar a individuos de alto riesgo. Un estudio evalúa la efectividad de los modelos predictivos que utilizan registros electrónicos de salud (EHR) para identificar grupos de alto riesgo al detectar señales prediagnósticas sutiles de cáncer. La investigación se centra en ocho tipos de cáncer importantes, incluidos el cáncer de mama y de pulmón, y compara los modelos basados en EHR con factores de riesgo tradicionales.

Les directives actuelles de dépistage du cancer sont limitées à quelques types de cancer et reposent sur des critères spécifiques tels que l'âge ou les antécédents de tabagisme pour identifier les individus à haut risque. Une étude évalue l'efficacité des modèles prédictifs utilisant des dossiers de santé électroniques (DSE) pour identifier les groupes à haut risque en détectant des signaux prédiagnostiques subtils du cancer. La recherche se concentre sur huit cancers majeurs, y compris le cancer du sein et du poumon, et compare les modèles basés sur les DSE aux facteurs de risque traditionnels.

Current cancer screening guidelines are limited to a few cancer types and rely on specific criteria like age or smoking history to identify high-risk individuals. A study evaluates the effectiveness of predictive models using electronic health records (EHRs) to identify high-risk groups by detecting subtle prediagnostic signals of cancer. The research focuses on eight major cancers, including breast and lung cancer, and compares EHR-based models to traditional risk factors. Evidence suggests EHR-based models may be more effective in identifying true cancer cases.

Toward Scalable Early Cancer Detection: Evaluating EHR-Based Predictive Models Against Traditional Screening Criteria

حقق Google Gemini 3 إنجازًا كبيرًا من خلال تجاوز جميع معايير الذكاء الاصطناعي الحالية، بما في ذلك الأكثر تحديًا. يبرز هذا الإنجاز التقدم الذي حققته فريق الذكاء الاصطناعي في Google ويضع Gemini 3 كمتنافس رائد في مجال الذكاء الاصطناعي. يتم الاحتفال بهذا النجاح داخل مجتمع التكنولوجيا، مما يعكس التطور المستمر لتقنيات الذكاء الاصطناعي وقدراتها.

Google Gemini 3 ha logrado un hito significativo al superar todos los benchmarks de IA existentes, incluidos los más desafiantes. Este logro resalta los avances realizados por el equipo de IA de Google y posiciona a Gemini 3 como un competidor líder en el panorama de la inteligencia artificial. El éxito es celebrado dentro de la comunidad tecnológica, reflejando la evolución continua de las tecnologías de IA y sus capacidades.

Google Gemini 3 a atteint un jalon significatif en surpassant tous les benchmarks d'IA existants, y compris les plus difficiles. Cet accomplissement met en évidence les avancées réalisées par l'équipe d'IA de Google et positionne Gemini 3 comme un concurrent de premier plan dans le paysage de l'intelligence artificielle. Le succès est célébré au sein de la communauté technologique, reflétant l'évolution continue des technologies d'IA et de leurs capacités.

Google Gemini 3 has achieved a significant milestone by surpassing all existing AI benchmarks, including the most challenging ones. This accomplishment highlights the advancements made by Google's AI team and positions Gemini 3 as a leading contender in the artificial intelligence landscape. The success is celebrated within the tech community, reflecting the ongoing evolution of AI technologies and their capabilities.

Google Gemini 3 Just Killed Every AI Benchmark, Including the Hardest of All

Two weeks ago I read a line about tool use with Claude that stuck in my head. Paraphrased:

<blockquote>
Direct tool calls don’t really scale. 
Have the model write code that uses tools, and execute that code instead.
</blockquote>

At the same time, I was knee-deep in wiring a JavaScript execution environment into Contenox, my self-hosted runtime for deterministic, chat-native AI workflows.

So of course the thought was:

<blockquote>
What if I just let the model write the JavaScript and run it inside the runtime? 😅
</blockquote>

This post is about what happened when I tried exactly that.




<h2>
 
 
 What is Contenox?
</h2>

Very short version:

<blockquote>
Contenox is a self-hostable runtime for sovereign GenAI applications. 
It models AI behavior as explicit state machines, not opaque prompt chains.
</blockquote>

Some key properties:

Runtime, not a library, Explicit state machines, Chat-native interface, Vendor-agnostic &amp; self-hosted, written in go with lots of passion and zero tolerance for shortcuts




<h2>
 
 
 The experiment: ask it to fetch and summarize a TODO
</h2>

Once the JS execution hook was in place (a Goja VM with some globals exposed), I wired up a new state machine: 


<div class="highlight js-code-highlight">
<pre class="highlight plaintext"><code>mux_input → moderate → generate_js → run_js → eval_js_result → (repair_js?) → answer
</code></pre>

</div>



Then I opened the Contenox chat UI and typed:

<blockquote>
Me: “Hey Contenox, fetch the TODO item from jsonplaceholder and summarize it.”
</blockquote>

The first attempt didn’t go as planned.

Instead of a neat summary, I got:

<blockquote>
Contenox: 
“I'm sorry, but it seems there was a problem fetching the TODO item from the provided URL due to an Internal Server Error (status code: 500). Unfortunately, I couldn't retrieve any data at this time. My apologies for the inconvenience!”
</blockquote>

I checked manually – Cloudflare was having a moment, JSONPlaceholder was behind it, and the request really was failing. Okay, fair. Long coffee break.

A bit later, I went back to the same chat and typed:

<blockquote>
Me: “okay let's try again now.”
</blockquote>

This time the reply was:

<blockquote>
Contenox: 
<code>Task titled "delectus aut autem" is incomplete. Nothing to summarize here.</code>
</blockquote>

Wait. It worked? Just like that?




<h2>
 
 
 Under the hood: LLM → JavaScript → tools → LLM
</h2>

Looking at the execution trace made it clear what happened.

<h3>
 
 
 1. Input is normalized and moderated
</h3>

The workflow starts with:

<ol>
<li><code>mux_input</code></li>
</ol>

<ul>
<li>
Parses the incoming chat history into a normalized <code>messages</code> array.

<ol>
<li><code>moderate</code></li>
</ol>
</li>
<li>Uses a small model to classify the input as safe/unsafe.</li>
<li>Output: <code>0</code> → safe → continue.</li>
</ul>

So far this is standard workflow stuff.

<h3>
 
 
 2. <code>generate_js</code>: the LLM writes JavaScript
</h3>

Next, the <code>generate_js</code> task runs with a system instruction like:

<ul>
<li>“You are an expert JavaScript agent for the Contenox runtime…”</li>
<li>“You must output JSON: { "code": "" }”</li>
<li>“You can use httpFetch, executeTask, executeTaskChain, …”</li>
<li>“Script must be synchronous, no async/await, and must return a JSON-serializable object.”</li>
</ul>

Given the chat history, the model produced something like this (simplified): 


<div class="highlight js-code-highlight">
<pre class="highlight json"><code>{
 "code": "var result;
var answer;
var meta = { steps: [] };

var todoUrl = \"https://jsonplaceholder.typicode.com/todos/1\";

// Step 1: Fetch the TODO item
meta.steps.push(\"Fetching TODO item from \" + todoUrl);
var fetchResponse = httpFetch(todoUrl);

if (!fetchResponse.ok) {
 answer = \"I couldn't access that item right now because there was some trouble with getting it. Please check the URL or try again later.\";
 meta.error = {
 message: \"HTTP fetch failed\",
 url: todoUrl,
 status: fetchResponse.status,
 statusText: fetchResponse.statusText,
 body: fetchResponse.body,
 error: fetchResponse.error
 };
 result = { answer: answer, meta: meta };
} else {
 var todoItem;
 try {
 todoItem = JSON.parse(fetchResponse.body);
 meta.raw = todoItem;
 } catch (e) {
 answer = \"I fetched the item, but I couldn't understand its format. It doesn't seem to be valid JSON.\";
 meta.error = {
 message: \"JSON parse error\",
 rawBody: fetchResponse.body,
 parseError: e.toString()
 };
 result = { answer: answer, meta: meta };
 }

 if (todoItem) {
 // Step 2: Summarize the TODO item using an LLM
 meta.steps.push(\"Summarizing TODO item with LLM\");
 var prompt = \"Summarize the following TODO item in a concise sentence: \" + JSON.stringify(todoItem);
 var summarizeTask = executeTask(prompt, \"gpt-4o-mini\", \"openai\");

 if (!summarizeTask.success) {
 answer = \"While I managed to fetch your TODO details, the summary tool had a hiccup and couldn't provide me with a concise sentence right now. We seem to be experiencing some temporary issues.\";
 meta.error = {
 message: \"LLM task execution failed\",
 task_id: summarizeTask.task_id,
 error: summarizeTask.error
 };
 result = { answer: answer, meta: meta };
 } else {
 answer = summarizeTask.response;
 meta.llmResponse = summarizeTask.response;
 result = { answer: answer, meta: meta };
 }
 }
}

result;"
}
</code></pre>

</div>



A few important details here:

<ul>
<li>
It encodes error handling:

<ul>
<li>If HTTP fails → user-friendly <code>answer</code>, raw error in <code>meta.error</code>.</li>
<li>If JSON parse fails → similar pattern.</li>
<li>If the inner LLM call fails → fallback message.</li>
</ul>


</li>

<li>It delegates the actual summarization to another model via <code>executeTask</code>.</li>

<li>It returns a structured <code>result</code> with both <code>answer</code> and <code>meta</code>.</li>

</ul>

This is not the model “calling tools” directly. It’s the model writing a program that calls tools.

<h3>
 
 
 3. <code>run_js</code>: execute the code in a sandbox
</h3>

The next task is <code>run_js</code>, which is just a Contenox <code>hook</code> that calls the JS sandbox: 


<div class="highlight js-code-highlight">
<pre class="highlight json"><code>{
 "name": "js_sandbox",
 "tool_name": "execute_js",
 "args": {
 "code": "{{.generate_js.code}}"
 }
}
</code></pre>

</div>



Inside the trace you can see:

<ul>
<li>An <code>httpFetch</code> log for the JSONPlaceholder URL.</li>
<li>A response with <code>status: 200 OK</code> when things finally worked.</li>
<li>
An <code>executeTask</code> log with the summarization prompt:

<ul>
<li><code>Summarize the following TODO item in a concise sentence: {"userId":1,"id":1,"title":"delectus aut autem","completed":false}</code></li>
</ul>


</li>

</ul>

The sandbox result looked roughly like: 


<div class="highlight js-code-highlight">
<pre class="highlight json"><code>{
 "ok": true,
 "result": {
 "answer": "Task titled \"delectus aut autem\" is incomplete.",
 "meta": {
 "llmResponse": "Task titled \"delectus aut autem\" is incomplete.",
 "raw": {
 "userId": 1,
 "id": 1,
 "title": "delectus aut autem",
 "completed": false
 },
 "steps": [
 "Fetching TODO item from https://jsonplaceholder.typicode.com/todos/1",
 "Summarizing TODO item with LLM"
 ]
 }
 },
 "logs": [ ... ],
 "code": "var result; ..."
}
</code></pre>

</div>



<h3>
 
 
 4. <code>eval_js_result</code>: success or retry?
</h3>

Now comes the evaluator:

<ul>
<li>It receives a description of the JS sandbox output.</li>
<li>
The system prompt is very strict:

<ul>
<li>If <code>ok</code> is true and there is a non-empty <code>result.answer</code> → respond with <code>success</code>.</li>
<li>Otherwise → respond with <code>retry</code>.</li>
</ul>


</li>

</ul>

On the successful run, it answered: 


<div class="highlight js-code-highlight">
<pre class="highlight plaintext"><code>success
</code></pre>

</div>



So the workflow does not go into <code>repair_js</code> or <code>run_js_retry</code>. Happy path.

<h3>
 
 
 5. <code>answer</code>: extract the final user message
</h3>

The final task, <code>answer</code>, is intentionally boring:

<ul>
<li>System prompt: “You are a purely extractive post-processor. Do NOT invent content. Just surface the best existing <code>answer</code> field.”
</li>
<li>
It gets:

<ul>
<li>First run (<code>run_js</code> result).</li>
<li>Second run (<code>run_js_retry</code>), if any.</li>
</ul>


</li>

<li>

Selection rule:

<ul>
<li>Take the last non-empty <code>answer</code> you see.</li>
<li>Output it verbatim.</li>
</ul>


</li>

</ul>

In our case it found: 


<div class="highlight js-code-highlight">
<pre class="highlight plaintext"><code>Task titled "delectus aut autem" is incomplete.
</code></pre>

</div>



And that’s exactly what Contenox replied in chat.




<h2>
 
 
 Why this is interesting (to me, at least)
</h2>

What I originally set out to build:

<blockquote>
A runtime for deterministic, observable GenAI workflows. 
Tasks, transitions, hooks – all explicit and replayable.
</blockquote>

What I accidentally stumbled into:

<blockquote>
A multi-model, self-orchestrating agent pattern, 
where LLMs write code that uses tools, and the runtime executes and evaluates that code.
</blockquote>

The pattern looks like this:

<ol>
<li>
Planner LLM (<code>generate_js</code>)</li>
</ol>

<ul>
<li>Reads user intent + history.</li>
<li>Emits JavaScript that calls <code>httpFetch</code>, <code>executeTask</code>, <code>executeTaskChain</code>, hooks, etc.</li>
</ul>

<ol>
<li>
Execution environment (<code>run_js</code> in Goja)</li>
</ol>

<ul>
<li>Deterministic execution of that JS.</li>
<li>Full logs of every HTTP call, every inner LLM call, every step.</li>
</ul>

<ol>
<li>
Controller LLM (<code>eval_js_result</code>)</li>
</ol>

<ul>
<li>Looks at the sandbox result.</li>
<li>Decides: is this good enough? Retry? Repair?</li>
</ul>

<ol>
<li>
Repair LLM (<code>repair_js</code>, if needed)</li>
</ol>

<ul>
<li>Gets the previous code + error output.</li>
<li>Writes a fixed version of the JS.</li>
</ul>

<ol>
<li>
Answer LLM (<code>answer</code>)</li>
</ol>

<ul>
<li>Doesn’t “reason” at all.</li>
<li>Just extracts the final <code>answer</code> text safely.</li>
</ul>

All of that is expressed as an explicit state machine in Contenox.

No hidden loops, no undocumented retries, no magic glue code inside some SDK. It’s all visible in the workflow graph and trace.




To me, that’s the exciting part:

<blockquote>
You don’t have to choose between “boring deterministic workflows” and “fancy agents”. 
You can build the agent on top of deterministic workflows. 
And everything stays **self-hosted, inspectable, and auditable if you want.
</blockquote>

يتناول المقال تجربة تم فيها السماح لنموذج ذكاء اصطناعي بكتابة كود جافا سكريبت داخل بيئة مستقلة تُدعى كونتينوكس. يتأمل الكاتب في مفهوم يتعلق باستخدام الأدوات في الذكاء الاصطناعي، مقترحًا أن النماذج يجب أن تولد كودًا لاستخدام الأدوات بدلاً من إجراء مكالمات مباشرة. تم اختبار هذا النهج من خلال تنفيذ كود جافا سكريبت الذي تم إنشاؤه داخل بيئة كونتينوكس، بهدف تحسين كفاءة سير العمل في الذكاء الاصطناعي.

El artículo discute un experimento en el que se permitió a un modelo de IA escribir código JavaScript dentro de un entorno autónomo llamado Contenox. El autor reflexiona sobre un concepto relacionado con el uso de herramientas en IA, sugiriendo que los modelos deberían generar código para utilizar herramientas en lugar de realizar llamadas directas. Este enfoque se probó ejecutando el JavaScript generado dentro del entorno Contenox, con el objetivo de mejorar la eficiencia de los flujos de trabajo de IA.

L'article traite d'une expérience où un modèle d'IA a été autorisé à écrire du code JavaScript au sein d'un environnement autonome appelé Contenox. L'auteur réfléchit à un concept concernant l'utilisation des outils en IA, suggérant que les modèles devraient générer du code pour utiliser des outils plutôt que d'effectuer des appels directs. Cette approche a été testée en exécutant le JavaScript généré dans l'environnement Contenox, visant à améliorer l'efficacité des flux de travail en IA.

The article discusses an experiment where an AI model was allowed to write JavaScript code within a self-hosted runtime called Contenox. The author reflects on a concept regarding tool usage in AI, suggesting that models should generate code to utilize tools instead of direct calls. This approach was tested by executing the generated JavaScript within the Contenox environment, aiming to enhance the efficiency of AI workflows.

I Let an LLM Write JavaScript Inside My AI Runtime. Here’s What Happened

Caterpillar Inc. was always an unlikely winner in the artificial intelligence craze. It makes the bulk of its money selling the equipment like yellow earth movers that has made it a stalwart of American industry.

تظهر شركة كاتربيلر كجهة غير متوقعة في قطاع الذكاء الاصطناعي، حيث تُعرف أساسًا بتصنيع الآلات الثقيلة مثل آلات الحفر. تاريخيًا، كانت الشركة تركز على المعدات الصناعية التقليدية، مما يجعلها أقل توافقًا مع الاتجاهات التكنولوجية المدفوعة بالذكاء الاصطناعي التي اجتذبت العديد من القطاعات الأخرى. على الرغم من الاهتمام المتزايد بالذكاء الاصطناعي، لا يزال النشاط الرئيسي لشركة كاتربيلر متجذرًا في الآلات المادية، مما قد يحد من جاذبيتها في مشهد تكنولوجي سريع التطور.

Caterpillar Inc. se ha presentado como un jugador improbable en el sector de la inteligencia artificial, siendo principalmente conocida por la fabricación de maquinaria pesada como las excavadoras. La compañía ha estado históricamente enfocada en equipos industriales tradicionales, lo que la hace menos alineada con las tendencias tecnológicas impulsadas por la IA que han cautivado a muchos otros sectores. A pesar del creciente interés en la IA, el negocio principal de Caterpillar sigue anclado en la maquinaria física, lo que podría limitar su atractivo en un paisaje tecnológico en rápida evolu…

Caterpillar Inc. se présente comme un acteur improbable dans le secteur de l'intelligence artificielle, étant principalement connu pour sa fabrication de machines lourdes telles que les pelles mécaniques. L'entreprise s'est historiquement concentrée sur l'équipement industriel traditionnel, ce qui la rend moins alignée avec les tendances technologiques axées sur l'IA qui ont captivé de nombreux autres secteurs. Malgré l'intérêt croissant pour l'IA, le cœur de métier de Caterpillar reste ancré dans la machinerie physique, ce qui pourrait limiter son attrait dans un paysage technologique en évol…

Caterpillar Inc. has emerged as an unlikely player in the artificial intelligence sector, primarily known for its manufacturing of heavy machinery such as earth movers. The company has historically focused on traditional industrial equipment, making it less aligned with the AI-driven technology trends that have captivated many other sectors. Despite the growing interest in AI, Caterpillar's core business remains rooted in physical machinery, which may limit its appeal in the rapidly evolving tech landscape.

Caterpillar’s Lone Bear Says Machinery Maker Is No AI Darling

<a href="https://www.techspot.com/news/110306-microsoft-explains-how-windows-11-become-agentic-os.html" target="_blank"><img src="https://www.techspot.com/images2/news/ts3_thumbs/2025/11/2025-11-18-ts3_thumbs-d01.jpg" width="800" height="560" style="padding: 15px 0" title="Microsoft explains how Windows 11 will become an agentic OS whether you like it or not" /></a> Windows president Pavan Davuluri recently described the future of Windows as an agentic operating system, where AI bots and large language models handle the user's commands on files and computing tasks. Critics mostly greeted the idea with scorn, cursing, and frustration over the "bug-ridden slop pile" the OS currently is.... <a href="https://www.techspot.com/news/110306-microsoft-explains-how-windows-11-become-agentic-os.html">Read Entire Article</a>

وصف رئيس شركة مايكروسوفت، بavan دافولوري، خطط ويندوز 11 للتطور إلى ما يسميه 'نظام تشغيل وكيل'. ستتضمن هذه التحويلة دمج روبوتات الذكاء الاصطناعي ونماذج اللغة الكبيرة لإدارة أوامر المستخدم ومهام الحوسبة. ومع ذلك، تم استقبال هذا الإعلان بسخرية وانتقادات من المستخدمين الذين يشعرون بالإحباط من الحالة الحالية لنظام التشغيل، الذي يصفونه بأنه مليء بالأخطاء.

El presidente de Microsoft, Pavan Davuluri, ha descrito los planes para que Windows 11 evolucione hacia lo que él llama un 'sistema operativo agente'. Esta transformación implicará la integración de bots de IA y modelos de lenguaje para gestionar los comandos y tareas informáticas del usuario. Sin embargo, el anuncio ha sido recibido con escepticismo y críticas por parte de los usuarios, que están frustrados con el estado actual del sistema operativo, que describen como plagado de errores.

Le président de Microsoft, Pavan Davuluri, a décrit les projets de Windows 11 pour évoluer vers ce qu'il appelle un 'système d'exploitation agentique'. Cette transformation impliquera l'intégration de bots IA et de modèles de langage pour gérer les commandes des utilisateurs et les tâches informatiques. Cependant, cette annonce a été accueillie avec scepticisme et critiques de la part des utilisateurs frustrés par l'état actuel du système d'exploitation, qu'ils décrivent comme rempli de bogues.

Microsoft's president, Pavan Davuluri, has outlined plans for Windows 11 to evolve into what he describes as an 'agentic operating system.' This transformation will involve the integration of AI bots and large language models to manage user commands and computing tasks. However, the announcement has been met with skepticism and criticism from users who are frustrated with the current state of the operating system, which they describe as plagued by bugs.

Microsoft explains how Windows 11 will become an agentic OS whether you like it or not

Although Black Friday is still two weeks away, you can find great Nintendo Switch and Switch 2 deals now. I've collected the best from Walmart, Best Buy, and more.

مع اقتراب يوم الجمعة السوداء بعد أسبوعين، تتوفر بالفعل عروض مبكرة على أجهزة نينتندو سويتش وسويتش 2. تقدم متاجر كبيرة مثل وول مارت وبيست باي أكثر من 20 عرضًا، مما يوفر للمستهلكين فرصة لتوفير المال على منتجات الألعاب الشهيرة قبل موسم التسوق للعطلات.

A medida que se acerca el Black Friday en dos semanas, ya están disponibles ofertas anticipadas en las consolas Nintendo Switch y Switch 2. Grandes minoristas como Walmart y Best Buy están ofreciendo más de 20 ventas, brindando a los consumidores la oportunidad de ahorrar en productos de videojuegos populares antes de la locura de compras navideñas.

À l'approche de Black Friday dans deux semaines, des offres anticipées sur les consoles Nintendo Switch et Switch 2 sont déjà disponibles. Des détaillants majeurs comme Walmart et Best Buy proposent plus de 20 ventes, offrant aux consommateurs l'occasion d'économiser sur des produits de jeu populaires avant la ruée des achats de vacances.

As Black Friday approaches in two weeks, early deals on Nintendo Switch and Switch 2 consoles are already available. Major retailers like Walmart and Best Buy are offering over 20 sales, providing consumers with an opportunity to save on popular gaming products ahead of the holiday shopping rush.

Best early Black Friday Nintendo Switch deals 2025: 20+ sales out early

<A HREF="https://substack.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.MstA6dhKs3CLxJgLSEpyVK_D4Oz9SmcjeXKNnqEDzIg?"><IMG VSPACE="4" HSPACE="4" BORDER="0" ALIGN="RIGHT" SRC="http://www.techmeme.com/251118/i47.jpg"></A>
<A HREF="http://www.techmeme.com/251118/p47#a251118p47" TITLE="Techmeme permalink"><IMG WIDTH=11 HEIGHT=12 SRC="http://www.techmeme.com/img/pml.png" STYLE="border:none;padding:0;margin:0;"></A> Alex Heath / <A HREF="https://sources.news/">Sources</A>: 
<A HREF="https://substack.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.MstA6dhKs3CLxJgLSEpyVK_D4Oz9SmcjeXKNnqEDzIg?">Q&amp;A with Demis Hassabis on Gemini 3, spending most of his research time on world models, fitting the entire Google Search index into Gemini, AI bubble, and more</A>&nbsp; &mdash;&nbsp; Demis Hassabis was noticeably relaxed when he joined our virtual call from London.&nbsp; &mdash;&nbsp; It was the day before the release of Gemini 3 &hellip;

ناقش ديميس هاسابيس، المؤسس المشارك لشركة ديب مايند، تقدم نموذج جيميني 3، أحدث نموذج للذكاء الاصطناعي من جوجل، مشددًا على قدراته في نمذجة العالم ودمج كامل فهرس بحث جوجل في النظام. تناول المخاوف بشأن فقاعة الذكاء الاصطناعي وأبرز إمكانيات النموذج في تحسين تفاعلات المستخدمين وتوفير معلومات أكثر دقة. تعكس أفكار هاسابيس التزامًا بدفع حدود تكنولوجيا الذكاء الاصطناعي ودمجها في التطبيقات اليومية.

Demis Hassabis, cofundador de DeepMind, discutió los avances de Gemini 3, el último modelo de IA de Google, enfatizando sus capacidades en modelos del mundo y la integración de todo el índice de búsqueda de Google en el sistema. Abordó las preocupaciones sobre la burbuja de la IA y destacó el potencial del modelo para mejorar las interacciones con los usuarios y proporcionar información más precisa. Las ideas de Hassabis reflejan un compromiso por llevar la tecnología de IA a nuevos límites y su integración en aplicaciones cotidianas.

Demis Hassabis, co-fondateur de DeepMind, a discuté des avancées de Gemini 3, le dernier modèle d'IA de Google, en mettant l'accent sur ses capacités en modélisation du monde et l'intégration de l'ensemble de l'index de recherche de Google dans le système. Il a abordé les préoccupations concernant la bulle de l'IA et a souligné le potentiel du modèle à améliorer les interactions avec les utilisateurs et à fournir des informations plus précises. Les réflexions de Hassabis reflètent un engagement à repousser les limites de la technologie IA et son intégration dans les applications quotidiennes.

Demis Hassabis, co-founder of DeepMind, discussed the advancements of Gemini 3, Google's latest AI model, emphasizing its capabilities in world modeling and fitting the entire Google Search index into the system. He addressed concerns about the AI bubble and highlighted the model's potential to enhance user interactions and provide more accurate information. Hassabis's insights reflect a commitment to pushing the boundaries of AI technology and its integration into everyday applications.

Q&A with Demis Hassabis on Gemini 3, spending most of his research time on world models, fitting the entire Google Search index into Gemini, AI bubble, and more (Alex Heath/Sources)

arXiv:2511.13082v1 Announce Type: new 
Abstract: Early diagnosis of breast cancer is crucial, enabling the establishment of appropriate treatment plans and markedly enhancing patient prognosis. While direct magnetic resonance imaging-guided biopsy demonstrates promising performance in detecting cancer lesions, its practical application is limited by prolonged procedure times and high costs. To overcome these issues, an indirect MRI-guided biopsy that allows the procedure to be performed outside of the MRI room has been proposed, but it still faces challenges in creating an accurate real-time deformable breast model. In our study, we tackled this issue by developing a graph neural network (GNN)-based model capable of accurately predicting deformed breast cancer sites in real time during biopsy procedures. An individual-specific finite element (FE) model was developed by incorporating magnetic resonance (MR) image-derived structural information of the breast and tumor to simulate deformation behaviors. A GNN model was then employed, designed to process surface displacement and distance-based graph data, enabling accurate prediction of overall tissue displacement, including the deformation of the tumor region. The model was validated using phantom and real patient datasets, achieving an accuracy within 0.2 millimeters (mm) for cancer node displacement (RMSE) and a dice similarity coefficient (DSC) of 0.977 for spatial overlap with actual cancerous regions. Additionally, the model enabled real-time inference and achieved a speed-up of over 4,000 times in computational cost compared to conventional FE simulations. The proposed deformation-aware GNN model offers a promising solution for real-time tumor displacement prediction in breast biopsy, with high accuracy and real-time capability. Its integration with clinical procedures could significantly enhance the precision and efficiency of breast cancer diagnosis.

أظهرت دراسة حديثة تطوير نموذج قائم على الشبكات العصبية الرسومية (GNN) للتنبؤ في الوقت الحقيقي بمواقع سرطان الثدي أثناء إجراءات الخزعة. يتناول هذا النموذج التحديات المتعلقة بإنشاء نماذج ثدي قابلة للتشوه بدقة، والتي تعتبر ضرورية للخزعات الموجهة بواسطة التصوير بالرنين المغناطيسي غير المباشر. من خلال دمج نماذج العناصر المحدودة الخاصة بكل فرد المستمدة من صور الرنين المغناطيسي، تهدف هذه الطريقة إلى تحسين دقة وكفاءة تشخيص سرطان الثدي، مما يعزز نتائج المرضى.

Un estudio reciente ha desarrollado un modelo basado en redes neuronales gráficas (GNN) para la predicción en tiempo real de sitios de cáncer de mama durante procedimientos de biopsia. Este modelo aborda los desafíos de crear modelos mamarios deformables precisos, que son esenciales para las biopsias guiadas por IRM indirectas. Al incorporar modelos de elementos finitos específicos de cada individuo derivados de imágenes de IRM, el enfoque busca mejorar la precisión y eficiencia del diagnóstico del cáncer de mama, mejorando así los resultados para los pacientes.

Une étude récente a développé un modèle basé sur un réseau de neurones graphiques (GNN) pour la prédiction en temps réel des sites de cancer du sein lors des procédures de biopsie. Ce modèle répond aux défis de la création de modèles mammaires déformables précis, essentiels pour les biopsies guidées par IRM indirectes. En intégrant des modèles d'éléments finis spécifiques à chaque individu dérivés d'images IRM, l'approche vise à améliorer la précision et l'efficacité du diagnostic du cancer du sein, améliorant ainsi les résultats pour les patients.

A recent study has developed a graph neural network (GNN)-based model for real-time prediction of breast cancer sites during biopsy procedures. This model addresses the challenges of creating accurate deformable breast models, which are essential for indirect MRI-guided biopsies. By incorporating individual-specific finite element models derived from MRI images, the approach aims to enhance the accuracy and efficiency of breast cancer diagnosis, ultimately improving patient outcomes.

Real-time prediction of breast cancer sites using deformation-aware graph neural network

arXiv:2511.08464v2 Announce Type: replace 
Abstract: Interpretability is essential in Whole Slide Image (WSI) analysis for computational pathology, where understanding model predictions helps build trust in AI-assisted diagnostics. While Integrated Gradients (IG) and related attribution methods have shown promise, applying them directly to WSIs introduces challenges due to their high-resolution nature. These methods capture model decision patterns but may overlook class-discriminative signals that are crucial for distinguishing between tumor subtypes. In this work, we introduce Contrastive Integrated Gradients (CIG), a novel attribution method that enhances interpretability by computing contrastive gradients in logit space. First, CIG highlights class-discriminative regions by comparing feature importance relative to a reference class, offering sharper differentiation between tumor and non-tumor areas. Second, CIG satisfies the axioms of integrated attribution, ensuring consistency and theoretical soundness. Third, we propose two attribution quality metrics, MIL-AIC and MIL-SIC, which measure how predictive information and model confidence evolve with access to salient regions, particularly under weak supervision. We validate CIG across three datasets spanning distinct cancer types: CAMELYON16 (breast cancer metastasis in lymph nodes), TCGA-RCC (renal cell carcinoma), and TCGA-Lung (lung cancer). Experimental results demonstrate that CIG yields more informative attributions both quantitatively, using MIL-AIC and MIL-SIC, and qualitatively, through visualizations that align closely with ground truth tumor regions, underscoring its potential for interpretable and trustworthy WSI-based diagnostics

تقدم الورقة البحثية طريقة جديدة تُعرف باسم التدرجات المتكاملة التباينية (CIG) لتعزيز قابلية الفهم في تحليل صور الشرائح الكاملة (WSI) في علم الأمراض الحاسوبي. تتناول هذه الطريقة التحديات التي تطرحها الصور عالية الدقة، مما يُحسن من تحديد الإشارات التمييزية بين الفئات الضرورية لتفريق الأنواع الفرعية للأورام. من خلال حساب التدرجات التباينية في فضاء اللوغيت، توفر CIG تمييزات أوضح بين المناطق الورمية وغير الورمية، مما يضمن الاتساق والصلابة النظرية في النسبة.

El artículo presenta los Gradientes Integrados Contrastivos (CIG), un nuevo método para mejorar la interpretabilidad en el análisis de Imágenes de Diapositiva Completa (WSI) en patología computacional. Los CIG abordan los desafíos que presentan las imágenes de alta resolución, mejorando la identificación de señales discriminativas de clase cruciales para la diferenciación de subtipos tumorales. Al calcular gradientes contrastivos en el espacio logit, los CIG proporcionan distinciones más claras entre áreas tumorales y no tumorales, asegurando consistencia y solidez teórica en la atribución.

Cet article présente les Gradients Intégrés Contrastifs (CIG), une nouvelle méthode visant à améliorer l'interprétabilité dans l'analyse des Images de Diapositive Entière (WSI) en pathologie computationnelle. Les CIG répondent aux défis posés par les images haute résolution, en améliorant l'identification des signaux discriminants de classe essentiels pour la différenciation des sous-types tumoraux. En calculant des gradients contrastifs dans l'espace logit, les CIG offrent des distinctions plus claires entre les zones tumorales et non tumorales, garantissant la cohérence et la solidité théori…

The paper introduces Contrastive Integrated Gradients (CIG), a new method for enhancing interpretability in Whole Slide Image (WSI) analysis within computational pathology. CIG addresses challenges posed by high-resolution images, improving the identification of class-discriminative signals crucial for tumor subtype differentiation. By computing contrastive gradients in logit space, CIG provides clearer distinctions between tumor and non-tumor areas, ensuring consistency and theoretical soundness in attribution.

Contrastive Integrated Gradients: A Feature Attribution-Based Method for Explaining Whole Slide Image Classification

arXiv:2511.08986v2 Announce Type: replace 
Abstract: Randomized controlled trials (RCTs) are indispensable for establishing the clinical value of medical artificial-intelligence (AI) tools, yet their high cost and long timelines hinder timely validation as new models emerge rapidly. Here, we propose BRIDGE, a data-reuse RCT design for AI-based risk models. AI risk models support a broad range of interventions, including screening, treatment selection, and clinical alerts. BRIDGE trials recycle participant-level data from completed trials of AI models when legacy and updated models make concordant predictions, thereby reducing the enrollment requirement for subsequent trials. We provide a practical checklist for investigators to assess whether reusing data from previous trials allows for valid causal inference and preserves type I error. Using real-world datasets across breast cancer, cardiovascular disease, and sepsis, we demonstrate concordance between successive AI models, with up to 64.8% overlap in top 5% high-risk cohorts. We then simulate a series of breast cancer screening studies, where our design reduced required enrollment by 46.6%--saving over US$2.8 million--while maintaining 80% power. By transforming trials into adaptive, modular studies, our proposed design makes Level I evidence generation feasible for every model iteration, thereby accelerating cost-effective translation of AI into routine care.

تعتبر التجارب السريرية العشوائية (RCTs) ضرورية لتأكيد الفعالية السريرية لأدوات الذكاء الاصطناعي الطبية، لكن تكاليفها العالية والجداول الزمنية الطويلة تشكل تحديات كبيرة. يقدم التصميم المقترح BRIDGE حلاً من خلال إعادة استخدام بيانات المشاركين من التجارب السابقة عندما تنتج نماذج الذكاء الاصطناعي تنبؤات متشابهة. يمكن أن يقلل هذا النهج من متطلبات التسجيل بنسبة 46.6% ويوفر أكثر من 2.8 مليون دولار مع الحفاظ على قوة إحصائية تبلغ 80%، مما يبرز إمكانيته في التحقق الفعال من نماذج الذكاء الاصطناعي في مجالات مثل سرطان الثدي وأمراض القلب والإنتان.

Los ensayos controlados aleatorios (ECA) son esenciales para validar la efectividad clínica de las herramientas de IA médica, pero sus altos costos y largos plazos presentan desafíos significativos. El diseño propuesto BRIDGE ofrece una solución al reutilizar datos de participantes de ensayos anteriores cuando los modelos de IA producen predicciones similares. Este enfoque puede reducir los requisitos de inscripción en un 46.6% y ahorrar más de 2.8 millones de dólares, manteniendo una potencia estadística del 80%, demostrando su potencial para una validación eficiente de modelos de IA en áreas…

Les essais contrôlés randomisés (ECR) sont essentiels pour valider l'efficacité clinique des outils d'IA médicale, mais leurs coûts élevés et leurs délais prolongés posent des défis importants. La conception proposée BRIDGE offre une solution en réutilisant les données des participants d'essais précédents lorsque les modèles d'IA produisent des prédictions similaires. Cette approche peut réduire les besoins d'inscription de 46,6 % et économiser plus de 2,8 millions de dollars tout en maintenant une puissance statistique de 80 %, démontrant son potentiel pour une validation efficace des modèles…

Randomized controlled trials (RCTs) are essential for validating the clinical effectiveness of medical AI tools, but their high costs and lengthy timelines pose significant challenges. The proposed BRIDGE design offers a solution by reusing participant-level data from previous trials when AI models yield similar predictions. This approach can significantly reduce enrollment requirements by 46.6% and save over $2.8 million while maintaining an 80% statistical power, demonstrating its potential for efficient AI model validation in areas like breast cancer, cardiovascular disease, and sepsis.

Data reuse enables cost-efficient randomized trials of medical AI models

arXiv:2511.10809v2 Announce Type: replace 
Abstract: Linear Predictive Clustering (LPC) partitions samples based on shared linear relationships between feature and target variables, with numerous applications including marketing, medicine, and education. Greedy optimization methods, commonly used for LPC, alternate between clustering and linear regression but lack global optimality. While effective for separable clusters, they struggle in non-separable settings where clusters overlap in feature space. In an alternative constrained optimization paradigm, Bertsimas and Shioda (2007) formulated LPC as a Mixed-Integer Program (MIP), ensuring global optimality regardless of separability but suffering from poor scalability. This work builds on the constrained optimization paradigm to introduce two novel approaches that improve the efficiency of global optimization for LPC. By leveraging key theoretical properties of separability, we derive near-optimal approximations with provable error bounds, significantly reducing the MIP formulation's complexity and improving scalability. Additionally, we can further approximate LPC as a Quadratic Pseudo-Boolean Optimization (QPBO) problem, achieving substantial computational improvements in some settings. Comparative analyses on synthetic and real-world datasets demonstrate that our methods consistently achieve near-optimal solutions with substantially lower regression errors than greedy optimization while exhibiting superior scalability over existing MIP formulations.

Near-optimal Linear Predictive Clustering in Non-separable Spaces via Mixed Integer Programming and Quadratic Pseudo-Boolean Reductions

arXiv:2511.07947v2 Announce Type: replace-cross 
Abstract: Machine learning models constitute valuable intellectual property, yet remain vulnerable to model extraction attacks (MEA), where adversaries replicate their functionality through black-box queries. Model watermarking counters MEAs by embedding forensic markers for ownership verification. Current black-box watermarks prioritize MEA survival through representation entanglement, yet inadequately explore resilience against sequential MEAs and removal attacks. Our study reveals that this risk is underestimated because existing removal methods are weakened by entanglement. To address this gap, we propose Watermark Removal attacK (WRK), which circumvents entanglement constraints by exploiting decision boundaries shaped by prevailing sample-level watermark artifacts. WRK effectively reduces watermark success rates by at least 88.79% across existing watermarking benchmarks.
  For robust protection, we propose Class-Feature Watermarks (CFW), which improve resilience by leveraging class-level artifacts. CFW constructs a synthetic class using out-of-domain samples, eliminating vulnerable decision boundaries between original domain samples and their artifact-modified counterparts (watermark samples). CFW concurrently optimizes both MEA transferability and post-MEA stability. Experiments across multiple domains show that CFW consistently outperforms prior methods in resilience, maintaining a watermark success rate of at least 70.15% in extracted models even under the combined MEA and WRK distortion, while preserving the utility of protected models.

Class-feature Watermark: A Resilient Black-box Watermark Against Model Extraction Attacks

arXiv:2511.06854v2 Announce Type: replace-cross 
Abstract: Irregularly sampled time series (ISTS), characterized by non-uniform time intervals with natural missingness, are prevalent in real-world applications. Existing approaches for ISTS modeling primarily rely on observed values to impute unobserved ones or infer latent dynamics. However, these methods overlook a critical source of learning signal: the reconstruction error inherently produced during model training. Such error implicitly reflects how well a model captures the underlying data structure and can serve as an informative proxy for unobserved values. To exploit this insight, we propose iTimER, a simple yet effective self-supervised pre-training framework for ISTS representation learning. iTimER models the distribution of reconstruction errors over observed values and generates pseudo-observations for unobserved timestamps through a mixup strategy between sampled errors and the last available observations. This transforms unobserved timestamps into noise-aware training targets, enabling meaningful reconstruction signals. A Wasserstein metric aligns reconstruction error distributions between observed and pseudo-observed regions, while a contrastive learning objective enhances the discriminability of learned representations. Extensive experiments on classification, interpolation, and forecasting tasks demonstrate that iTimER consistently outperforms state-of-the-art methods under the ISTS setting.

تُعتبر السلاسل الزمنية المأخوذة بشكل غير منتظم (ISTS) شائعة في التطبيقات الواقعية، حيث تتميز بفترات زمنية غير متساوية وغيابات طبيعية. تعتمد الأساليب الحالية لنمذجة ISTS بشكل أساسي على القيم المرصودة لاستنتاج القيم غير المرصودة، متجاهلة إشارة التعلم الناتجة عن خطأ إعادة البناء الذي يتم إنتاجه أثناء تدريب النموذج. يقترح الإطار المقترح iTimER استغلال هذا الخطأ في إعادة البناء لتحسين تعلم التمثيل من خلال توليد ملاحظات زائفة للعلامات الزمنية غير المرصودة، مما يحسن نمذجة ISTS.

Las series temporales muestreadas de manera irregular (ISTS) son comunes en aplicaciones del mundo real, caracterizadas por intervalos de tiempo no uniformes y ausencias naturales. Los métodos existentes para la modelización de ISTS suelen depender de valores observados para inferir los no observados, ignorando la señal de aprendizaje proveniente del error de reconstrucción generado durante el entrenamiento del modelo. El marco propuesto iTimER aprovecha este error de reconstrucción para mejorar el aprendizaje de la representación generando pseudo-observaciones para marcas de tiempo no observa…

Les séries temporelles échantillonnées de manière irrégulière (ISTS) sont courantes dans les applications réelles, caractérisées par des intervalles de temps non uniformes et des absences naturelles. Les méthodes traditionnelles de modélisation des ISTS s'appuient souvent sur des valeurs observées pour inférer celles non observées, négligeant le signal d'apprentissage provenant de l'erreur de reconstruction produite lors de l'entraînement du modèle. Le cadre proposé iTimER exploite cette erreur de reconstruction pour améliorer l'apprentissage de la représentation en générant des pseudo-observa…

Irregularly sampled time series (ISTS) are common in real-world applications, characterized by non-uniform time intervals and natural missingness. Traditional ISTS modeling methods often rely on observed values to infer unobserved ones, neglecting the learning signal from reconstruction error produced during model training. The proposed iTimER framework leverages this reconstruction error to enhance representation learning by generating pseudo-observations for unobserved timestamps, thus improving the modeling of ISTS.

Toward Scalable Early Cancer Detection: Evaluating EHR-Based Predictive Models Against Traditional Screening Criteria

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