Joint Progression Modeling (JPM): A Probabilistic Framework for Mixed-Pathology Progression

arXiv — cs.LGThursday, December 4, 2025 at 5:00:00 AM
  • The Joint Progression Model (JPM) has been introduced as a probabilistic framework designed to analyze mixed-pathology progression in neurodegenerative diseases, moving beyond traditional event-based models that assume a single disease per individual. This framework evaluates various JPM variants and their effectiveness in predicting disease trajectories based on partial rankings.
  • The development of JPM is significant as it enhances the understanding of complex neurodegenerative conditions, such as Alzheimer's disease (AD) and vascular dementia (VaD), by providing a more nuanced approach to modeling disease progression, which could lead to improved patient outcomes and tailored treatment strategies.
  • This advancement reflects a growing trend in the field of artificial intelligence and machine learning, where probabilistic methods are increasingly utilized to address the complexities of medical data, including the detection of anomalies and change points in disease progression, thereby fostering a deeper understanding of multifaceted health issues.
— via World Pulse Now AI Editorial System

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