Copula Based Fusion of Clinical and Genomic Machine Learning Risk Scores for Breast Cancer Risk Stratification

arXiv — cs.LGTuesday, November 25, 2025 at 5:00:00 AM
  • A recent study utilized the METABRIC breast cancer cohort to explore the effectiveness of copula-based fusion of clinical and genomic machine learning risk scores for predicting 5-year cancer-specific mortality. By modeling the joint relationship between clinical variables and genomic data, researchers aimed to enhance risk stratification beyond traditional linear methods.
  • This development is significant as it offers a more nuanced approach to breast cancer risk assessment, potentially leading to improved patient outcomes through better-targeted interventions and personalized treatment plans based on individual risk profiles.
  • The integration of advanced machine learning techniques, such as Random Forest and XGBoost, reflects a broader trend in healthcare towards leveraging data-driven insights for disease prediction and management. This approach aligns with ongoing efforts to enhance diagnostic accuracy across various medical fields, including cardiac and smoking-related health risks, highlighting the versatility and importance of machine learning in modern medicine.
— via World Pulse Now AI Editorial System

Was this article worth reading? Share it

Recommended apps based on your readingExplore all apps
Continue Readings
When Active Learning Fails, Uncalibrated Out of Distribution Uncertainty Quantification Might Be the Problem
NeutralArtificial Intelligence
A recent study highlights the challenges of estimating prediction uncertainty in active learning campaigns for materials discovery, indicating that uncalibrated out-of-distribution uncertainty quantification may hinder model performance. The research evaluates various uncertainty estimation methods using ensembles of ALIGNN, eXtreme Gradient Boost, Random Forest, and Neural Network architectures, focusing on tasks related to solubility, bandgap, and formation energy predictions.
AI-based framework to predict animal and pen feed intake in feedlot beef cattle
PositiveArtificial Intelligence
An AI-based framework has been developed to predict feed intake for individual beef cattle and pen-level aggregation, utilizing data from 19 experiments conducted at the Nancy M. Cummings Research Extension & Education Center in Carmen, ID, alongside environmental data from AgriMet Network weather stations. This framework aims to leverage big data generated by electronic feeding systems to enhance precision livestock farming practices.
Leveraging Spatiotemporal Graph Neural Networks for Multi-Store Sales Forecasting
PositiveArtificial Intelligence
A recent study has demonstrated the effectiveness of spatiotemporal Graph Neural Networks (GNNs) in forecasting multi-store retail sales, specifically using data from 45 Walmart locations. The research highlights the STGNN's ability to model inter-store dependencies and achieve lower forecasting errors compared to traditional methods like ARIMA, LSTM, and XGBoost.
Upstream Probabilistic Meta-Imputation for Multimodal Pediatric Pancreatitis Classification
PositiveArtificial Intelligence
A new study introduces Upstream Probabilistic Meta-Imputation (UPMI) as a novel strategy for classifying pediatric pancreatitis, a complex inflammatory condition. This method leverages machine learning techniques to enhance diagnostic accuracy by utilizing a low-dimensional meta-feature space, addressing challenges posed by limited sample sizes and the intricacies of multimodal imaging.
Less Is More: An Explainable AI Framework for Lightweight Malaria Classification
PositiveArtificial Intelligence
A new study introduces the Extracted Morphological Feature Engineered (EMFE) pipeline, a lightweight machine learning approach for malaria classification that achieves performance levels comparable to deep learning models while requiring significantly less computational power. This method utilizes the NIH Malaria Cell Images dataset, focusing on simple cell morphology features such as non-background pixels and holes within cells.
Finding Pre-Injury Patterns in Triathletes from Lifestyle, Recovery and Load Dynamics Features
PositiveArtificial Intelligence
A new study has introduced a synthetic data generation framework aimed at identifying pre-injury patterns in triathletes by analyzing lifestyle, recovery, and load dynamics features. This framework generates physiologically plausible athlete profiles and simulates individualized training programs while considering factors such as sleep quality and stress levels, which are often overlooked in injury prediction models.
Enhancing Breast Cancer Prediction with LLM-Inferred Confounders
PositiveArtificial Intelligence
A recent study has enhanced breast cancer prediction by utilizing large language models (LLMs) to infer the likelihood of confounding diseases such as diabetes, obesity, and cardiovascular disease from routine clinical data. This innovative approach has shown to improve the performance of Random Forest models, with notable enhancements from models like Gemma and Llama, indicating a significant advancement in predictive analytics for breast cancer.
The Impact of Feature Scaling In Machine Learning: Effects on Regression and Classification Tasks
PositiveArtificial Intelligence
A recent study published on arXiv systematically evaluated 12 feature scaling techniques across 14 machine learning algorithms and 16 datasets, revealing significant performance variations in models like Logistic Regression and SVMs, while ensemble methods showed robustness regardless of scaling.