The Alignment Paradox of Medical Large Language Models in Infertility Care: Decoupling Algorithmic Improvement from Clinical Decision-making Quality

arXiv — cs.LGTuesday, November 25, 2025 at 5:00:00 AM
  • A recent study evaluated the alignment of large language models (LLMs) in infertility care, assessing four strategies: Supervised Fine-Tuning (SFT), Direct Preference Optimization (DPO), Group Relative Policy Optimization (GRPO), and In-Context Learning (ICL). The findings revealed that GRPO achieved the highest algorithmic accuracy, while clinicians preferred SFT for its clearer reasoning and therapeutic feasibility.
  • This development is significant as it highlights the ongoing challenge of integrating advanced AI models into clinical decision-making, particularly in sensitive areas like infertility care. The preference for SFT by clinicians underscores the importance of interpretability and practical applicability in medical AI.
  • The findings reflect broader discussions in the AI field regarding the balance between algorithmic performance and human-centered design. Issues such as hallucination mitigation, bias in model outputs, and the need for diverse reasoning capabilities are critical as LLMs are increasingly utilized in healthcare settings.
— via World Pulse Now AI Editorial System

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