BeeTLe: An Imbalance-Aware Deep Sequence Model for Linear B-Cell Epitope Prediction and Classification with Logit-Adjusted Losses

arXiv — cs.LGWednesday, December 10, 2025 at 5:00:00 AM
  • A new deep learning-based framework named BeeTLe has been introduced for the prediction and classification of linear B-cell epitopes, which are critical for understanding immune responses and developing vaccines and therapeutics. This model employs a sequence-based neural network with recurrent layers and Transformer blocks, enhancing the accuracy of epitope identification.
  • The development of BeeTLe is significant as it addresses the limitations of existing epitope prediction tools, which often fail to distinguish effectively between epitopes and non-epitopes. By improving prediction accuracy, this model could accelerate vaccine development and therapeutic strategies.
  • This advancement in deep learning for epitope prediction aligns with ongoing efforts in the biomedical field to automate and enhance diagnostic processes, as seen in other studies focusing on antinuclear antibody detection and biomedical segmentation. The integration of sophisticated machine learning techniques is becoming increasingly vital in addressing complex challenges in immunology and cancer research.
— via World Pulse Now AI Editorial System

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