Knowledge-Guided Brain Tumor Segmentation via Synchronized Visual-Semantic-Topological Prior Fusion

arXiv — cs.CVThursday, November 13, 2025 at 5:00:00 AM
The introduction of Synchronized Tri-modal Prior Fusion (STPF) marks a significant advancement in brain tumor segmentation, addressing the limitations of existing deep learning methods that primarily focus on visual features. By incorporating pathology-driven differential features, unsupervised semantic descriptions, and geometric constraints through persistent homology analysis, STPF achieves a mean Dice coefficient of 0.868 on the BraTS 2020 dataset, surpassing previous models by 2.6 percentage points. This improvement is critical as accurate tumor delineation is essential for effective treatment planning. The method's stable performance, demonstrated through five-fold cross-validation with coefficients of variation between 0.23% and 0.33%, further underscores its reliability. As the medical field increasingly relies on AI for diagnostic and treatment processes, innovations like STPF are vital for enhancing patient outcomes.
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