Surrogate modeling of Cellular-Potts Agent-Based Models as a segmentation task using the U-Net neural network architecture

arXiv — cs.LGWednesday, November 5, 2025 at 5:00:00 AM

Surrogate modeling of Cellular-Potts Agent-Based Models as a segmentation task using the U-Net neural network architecture

A recent study explores the use of a convolutional neural network (CNN), specifically the U-Net architecture, to improve the efficiency of Cellular-Potts models, which are agent-based simulations vital for modeling complex biological systems. The research frames surrogate modeling of these Cellular-Potts models as a segmentation task, leveraging the strengths of CNNs in image processing to address computational challenges inherent in traditional approaches. By doing so, the study aims to enhance the applicability of Cellular-Potts models in biological research, where computational cost has been a limiting factor. This approach supports the broader goal of making detailed biological simulations more accessible and efficient. The work aligns with ongoing efforts to integrate machine learning techniques into biological modeling, reflecting a trend toward hybrid computational methods. Overall, the study presents a promising direction for surrogate modeling that could facilitate more rapid and scalable biological simulations.

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