Sorfequiline shows stronger action than existing treatments against illness that killed 1.23 million last yearA new treatment for tuberculosis could boost cure rates and shorten the time needed to treat the disease by months, trial results suggest.Globally, an estimated 10.7 million people fell ill with TB last year and 1.23 million died from it. <a href="https://www.theguardian.com/global-development/2025/nov/19/new-drug-could-be-breakthrough-killer-tb-tuberculosis-sorfequiline">Continue reading...</a>

أظهر دواء جديد، سورفيكويلين، نتائج واعدة في التجارب لعلاج مرض السل، مما قد يزيد من معدلات الشفاء ويقلل من مدة العلاج. العام الماضي، أصيب حوالي 10.7 مليون شخص بالسل في جميع أنحاء العالم، مما أدى إلى وفاة 1.23 مليون شخص.

Un nuevo fármaco, Sorfequiline, ha mostrado resultados prometedores en ensayos para el tratamiento de la tuberculosis (TB), lo que podría aumentar las tasas de curación y reducir la duración del tratamiento. El año pasado, la TB afectó a aproximadamente 10.7 millones de personas en todo el mundo, causando 1.23 millones de muertes.

Un nouveau médicament, Sorfequiline, a montré des résultats prometteurs lors des essais pour le traitement de la tuberculose (TB), augmentant potentiellement les taux de guérison et réduisant la durée du traitement. L'année dernière, la TB a touché environ 10,7 millions de personnes dans le monde, entraînant 1,23 million de décès.

A new drug, Sorfequiline, has shown promising results in trials for treating tuberculosis (TB), potentially increasing cure rates and reducing treatment duration. Last year, TB affected an estimated 10.7 million people globally, leading to 1.23 million deaths.

New drug could be a breakthrough in treatment for killer TB, trial suggests

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Amazon just dropped its best Black Friday deals on Kindles including the Paperwhite and Scribe

As the Cop30 climate talks continue in Brazil, Madeleine Finlay hears about a landscape at the opposite end of the planet facing the direct impacts of the climate crisis. The Guardian reporter Leyland Cecco recounts a recent trip to Qikiqtaruk (also known as Herschel Island) off the coast of Canada’s Yukon territory, where he saw first hand how indigenous groups and scientists are reckoning with an ecosystem collapsing into the sea. He tells Madeleine about efforts to preserve the history of the island and how scientists are racing to understand what it means for the fate of other arctic communities.<a href="https://www.theguardian.com/environment/2024/nov/21/canada-arctic-herschel-island-qikiqtaruk-climate-permafrost-tundra-ecology-aoe">‘The land is tearing itself apart’: life on a collapsing Arctic isle</a>Support the Guardian: <a href="http://theguardian.com/sciencepod">theguardian.com/sciencepod</a> <a href="https://www.theguardian.com/science/audio/2025/nov/20/chunks-of-earth-just-disappear-life-on-a-collapsing-island-podcast">Continue reading...</a>

بينما تستمر محادثات المناخ في مؤتمر COP30 في البرازيل، يشارك لييلاند تشيكو من صحيفة الغارديان رؤاه من زيارته إلى كيكيتاروك (جزيرة هيرشل) في إقليم يوكون بكندا. يسلط الضوء على التأثيرات المقلقة لتغير المناخ على الجزيرة، حيث تشهد المجتمعات الأصلية والعلماء تآكل الأرض في البحر. تُبذل جهود لتوثيق تاريخ الجزيرة وفهم الآثار المترتبة على المجتمعات القطبية الأخرى التي تواجه تحديات مماثلة.

Mientras continúan las conversaciones climáticas de la Cop30 en Brasil, Leyland Cecco de The Guardian comparte sus observaciones de su visita a Qikiqtaruk (Isla Herschel) en el territorio de Yukon, Canadá. Destaca los alarmantes efectos del cambio climático en la isla, donde comunidades indígenas y científicos son testigos de la erosión de la tierra hacia el mar. Se están realizando esfuerzos para documentar la historia de la isla y entender las implicaciones para otras regiones árticas que enfrentan desafíos similares.

Alors que les négociations climatiques de la Cop30 se déroulent au Brésil, Leyland Cecco du Guardian partage ses observations lors de sa visite à Qikiqtaruk (île Herschel) dans le territoire du Yukon au Canada. Il met en lumière les effets alarmants du changement climatique sur l'île, où les communautés autochtones et les scientifiques sont témoins de l'érosion des terres dans la mer. Des efforts sont en cours pour documenter l'histoire de l'île et comprendre les implications pour d'autres régions arctiques confrontées à des défis similaires.

As the Cop30 climate talks unfold in Brazil, Leyland Cecco from The Guardian shares insights from his visit to Qikiqtaruk (Herschel Island) in Canada’s Yukon territory. He highlights the alarming effects of climate change on the island, where indigenous communities and scientists are witnessing the land erode into the sea. Efforts are underway to document the island's history and understand the implications for other Arctic regions facing similar challenges.

‘Chunks of earth just disappear’: life on a collapsing island – podcast

Australia will now support the Turkish bid to host the climate talks in return for their minister chairing them.

Turkey set to host COP31 after reaching compromise with Australia

Conservation can be tough when a property is passed down informally over generations. A growing effort is helping families sort it all out.

They Loved Their Family Land in South Carolina. But Who Actually Owned It?

With the government reopened, the space agency at last released pictures captured by a fleet of government spacecraft of an object that came from beyond our solar system.

أصدرت وكالة ناسا صورًا للمذنب 3I/ATLAS أثناء مروره بالقرب من المريخ، بعد إعادة فتح الحكومة. تم التقاط الصور بواسطة أسطول من المركبات الفضائية الحكومية، مما يظهر جسمًا جاء من خارج نظامنا الشمسي.

NASA ha publicado imágenes de la cometa 3I/ATLAS mientras pasaba cerca de Marte, tras la reapertura del gobierno. Las imágenes fueron capturadas por una flota de naves espaciales gubernamentales, mostrando un objeto que proviene de más allá de nuestro sistema solar.

NASA a publié des images de la comète 3I/ATLAS alors qu'elle passait près de Mars, suite à la réouverture du gouvernement. Les images ont été capturées par une flotte de vaisseaux spatiaux gouvernementaux, montrant un objet originaire d'au-delà de notre système solaire.

NASA has released images of Comet 3I/ATLAS as it passed by Mars, following the reopening of the government. The images were captured by a fleet of government spacecraft, showcasing an object that originated from beyond our solar system.

NASA Releases Images of Comet 3I/ATLAS Passing by Mars

The interstellar visitor, known as 3I/Atlas, will be seen just in this instance, never to come back againNasa released close-up pictures on Wednesday of the <a href="https://apnews.com/article/interstellar-comet-nasa-b9df6568efee22c02b722a87377d30db">interstellar comet</a> that’s making a quick one-and-done tour of the solar system.<a href="https://apnews.com/article/new-comet-nasa-3iatlas-83646ec002106c8ff89757330c69bfe8">Discovered over the summer</a>, the comet known as 3I/Atlas is only the third confirmed object to visit our corner of the cosmos from another star. It zipped harmlessly past Mars last month. <a href="https://www.theguardian.com/science/2025/nov/19/nasa-interstellar-comet-pictures">Continue reading...</a>

Nasa releases close-up pictures of comet flying by from another star system

Study calls for depression treatment to be suspended for more research after reports of heart problems and emotional bluntingElectroconvulsive therapy could be causing a wider range of adverse effects when used to treat depression than previously understood, according to a paper that calls for the practice to be suspended pending more robust research.Although short- and long-term memory loss is widely known to result from ECT, the research identified 25 further concerning side effects, which included cardiovascular problems, fatigue and emotional blunting. <a href="https://www.theguardian.com/science/2025/nov/20/depression-electroconvulsive-therapy-adverse-effects-study">Continue reading...</a>

تشير دراسة حديثة إلى أن العلاج بالصدمات الكهربائية (ECT) قد يؤدي إلى مجموعة أوسع من الآثار الجانبية السلبية مما كان يُعتقد سابقًا، مما يستدعي الدعوة إلى تعليق استخدامه حتى يتم إجراء المزيد من الأبحاث. على الرغم من أن فقدان الذاكرة هو نتيجة معروفة للعلاج بالصدمات الكهربائية، فقد حدد الباحثون 25 أثرًا جانبيًا مقلقًا إضافيًا، بما في ذلك مشاكل القلب، والتعب، وتخدير المشاعر.

Un estudio reciente sugiere que la terapia electroconvulsiva (ECT) puede causar una gama más amplia de efectos adversos de lo que se pensaba anteriormente, lo que ha llevado a solicitar la suspensión de su uso hasta que se realicen más investigaciones. Aunque la pérdida de memoria es una consecuencia conocida de la ECT, los investigadores identificaron 25 efectos secundarios preocupantes adicionales, incluidos problemas cardiovasculares, fatiga y embotamiento emocional.

Une étude récente suggère que la thérapie électroconvulsive (ECT) pourrait entraîner une gamme d'effets indésirables plus large que ce qui était précédemment reconnu, incitant à suspendre son utilisation jusqu'à ce que des recherches supplémentaires soient menées. Bien que la perte de mémoire soit une conséquence connue de l'ECT, les chercheurs ont identifié 25 effets secondaires préoccupants supplémentaires, notamment des problèmes cardiovasculaires, de la fatigue et un émoussement émotionnel.

A recent study suggests that electroconvulsive therapy (ECT) may lead to a broader range of adverse effects than previously recognized, prompting calls for a suspension of its use until further research is conducted. While memory loss is a known consequence of ECT, researchers identified 25 additional concerning side effects, including cardiovascular issues, fatigue, and emotional blunting.

Electroconvulsive therapy may have more adverse effects than thought

Molecular profiles will give detailed snapshot of person’s physiology and predict diseases from diabetes to cancer and dementiaThe world’s largest study into key substances in the bloodstream has paved the way for a swathe of pinprick tests that can detect early signs of disease more than a decade before symptoms appear, researchers say.Work on the tests follows the completion of a project by the UK Biobank to measure the levels of nearly 250 different proteins, sugars, fats and other compounds in blood collected from half a million volunteers. <a href="https://www.theguardian.com/science/2025/nov/20/pinprick-blood-test-could-detect-disease-10-years-before-symptoms-appear-study">Continue reading...</a>

تشير دراسة جديدة إلى أن اختبارات الدم بواسطة وخز الإصبع يمكن أن تكشف عن أمراض مثل السكري والسرطان والخرف قبل عشر سنوات من ظهور الأعراض. تستند هذه الأبحاث إلى تحليل بنك البيانات البريطاني لمستويات ما يقرب من 250 مكونًا مختلفًا في الدم من نصف مليون متطوع، وتهدف إلى إنشاء مجموعة من الاختبارات التي تقدم لمحات تفصيلية عن الفسيولوجيا البشرية.

Un nuevo estudio indica que las pruebas de sangre por punción podrían identificar enfermedades como la diabetes, el cáncer y la demencia hasta diez años antes de que aparezcan los síntomas. Esta investigación, que proviene del análisis del UK Biobank de casi 250 componentes sanguíneos diferentes de medio millón de voluntarios, tiene como objetivo crear una gama de pruebas que proporcionen información fisiológica detallada.

Une nouvelle étude révèle que des tests sanguins par piqûre pourraient détecter des maladies telles que le diabète, le cancer et la démence jusqu'à dix ans avant l'apparition des symptômes. Cette recherche, issue de l'analyse par le UK Biobank de près de 250 composants sanguins différents provenant de cinq cent mille volontaires, vise à créer une gamme de tests fournissant des informations physiologiques détaillées.

A new study indicates that pinprick blood tests could identify diseases such as diabetes, cancer, and dementia up to ten years before symptoms manifest. This research, stemming from the UK Biobank's analysis of nearly 250 different blood components from half a million volunteers, aims to create a range of tests that provide detailed physiological insights.

New drug could be a breakthrough in treatment for killer TB, trial suggests

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