Arizona Cardinals vs. San Francisco 49ers opponent preview, picks and predictions

Yahoo SportsSunday, September 21, 2025 at 5:14:02 AM
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As the Arizona Cardinals prepare to face the San Francisco 49ers in Week 3, insights from Niners Nation's Kyle Posey and Jess Root highlight key matchups and predictions. This game is significant as it could set the tone for both teams' seasons, making it a must-watch for fans eager to see how the Cardinals stack up against a strong rival.
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