When Genes Speak: A Semantic-Guided Framework for Spatially Resolved Transcriptomics Data Clustering

arXiv — cs.LGMonday, November 17, 2025 at 5:00:00 AM
  • SemST has been introduced as a novel framework that enhances spatial transcriptomics data clustering by leveraging the semantic meanings of genes through Large Language Models. This approach allows for a more nuanced understanding of gene expression in relation to tissue microenvironments.
  • The development of SemST is significant as it addresses the limitations of traditional computational models that treat genes as isolated features, thereby improving the biological insights derived from transcriptomics data. This advancement could lead to breakthroughs in understanding complex biological systems.
  • While there are no directly related articles, the introduction of SemST aligns with ongoing trends in AI and deep learning applications in biology, emphasizing the importance of integrating semantic understanding with computational methods to advance research in gene expression analysis.
— via World Pulse Now AI Editorial System

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