Supervise Less, See More: Training-free Nuclear Instance Segmentation with Prototype-Guided Prompting

arXiv — cs.CVWednesday, November 26, 2025 at 5:00:00 AM
  • A new framework named SPROUT has been introduced for nuclear instance segmentation, eliminating the need for training and annotations. This method utilizes histology-informed priors to create slide-specific reference prototypes, which help in aligning features and improving segmentation accuracy in computational pathology.
  • The development of SPROUT is significant as it addresses the limitations of existing models that require extensive supervision and fine-tuning, thereby streamlining the process of nuclear instance segmentation and potentially enhancing clinical insights.
  • This advancement reflects a broader trend in artificial intelligence towards training-free methodologies, as seen in other models like UnSAMv2 and various adaptations of the Segment Anything Model (SAM), which aim to improve segmentation granularity and efficiency in medical imaging.
— via World Pulse Now AI Editorial System

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