From Macro to Micro: Benchmarking Microscopic Spatial Intelligence on Molecules via Vision-Language Models

arXiv — cs.CVFriday, December 12, 2025 at 5:00:00 AM
  • A new framework called Microscopic Spatial Intelligence (MiSI) has been introduced to benchmark the capabilities of Vision-Language Models (VLMs) in understanding spatial relationships of microscopic entities. The MiSI-Bench includes over 163,000 question-answer pairs and 587,000 images from around 4,000 molecular structures, highlighting the performance gap between VLMs and human capabilities in spatial reasoning tasks.
  • This development is significant as it establishes a systematic approach to evaluate VLMs, revealing their limitations in scientific tasks while showcasing the potential of fine-tuned models that can outperform humans in specific spatial transformations.
  • The introduction of MiSI-Bench aligns with ongoing efforts to enhance VLMs through various frameworks that improve multimodal reasoning and spatial understanding. These advancements underscore a broader trend in AI research focused on bridging the gap between human-like reasoning and machine learning capabilities, particularly in complex scientific domains.
— via World Pulse Now AI Editorial System

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