Robust Atypical Mitosis Classification with DenseNet121: Stain-Aware Augmentation and Hybrid Loss for Domain Generalization

arXiv — cs.CVTuesday, November 4, 2025 at 5:00:00 AM

Robust Atypical Mitosis Classification with DenseNet121: Stain-Aware Augmentation and Hybrid Loss for Domain Generalization

A new framework using DenseNet-121 has been developed to improve the classification of atypical mitotic figures, which are crucial indicators of tumor aggressiveness in histopathology. This method addresses challenges like class imbalance and variability in imaging, making it a significant advancement for researchers and clinicians. By incorporating stain-aware augmentation and various transformations, this approach aims to enhance the reliability of mitosis recognition, ultimately aiding in better cancer diagnosis and treatment.
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